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A plugin runtime for software that iterates on itself — the substrate where agents write, swap and hot-reload their own plugins in Rust, TypeScript, Python and Go, across processes and machines.

Python module for prior knowledge integration. Builds databases of signaling pathways, enzyme-substrate interactions, complexes, annotations and intercellular communication roles.

A cross-platform render-graph based rendering system written in Swift

One Stake, Endless Opportunities. Build with Polkadot SDK (Substrate).

Interact with Substrate based nodes in Rust or WebAssembly

Acala - cross-chain DeFi hub and stablecoin based on Substrate for Polkadot and Kusama.

A cli tool to easily spawn ephemeral Polkadot/Substrate networks and perform tests against them.

Microbus is the only fabric where every agentic workflow runs on a true microservice substrate - giving your workflows security, scale, observability, and prompt-driven authoring.

Create parallel reality of your Substrate network.

zkVerify is a highly performant, secure, and decentralized Substrate-based blockchain for zero-knowledge (ZK) proof verification, that substantially lowers the costs of verification and extends the range of possibilities within Web3 to use different cryptographic primitives and systems.

An Open-source Framework for Human Understanding, Meaning, and Progress.

An EVM compatible Substrate chain, powered by StorageHub and secured by EigenLayer

A rust implementation of the Quip Protocol forked from Substrate

Operations substrate for AI agents that use real software: 311 sites/tools, logged-in browsers, desktop apps, local tools, MCP, policy, evidence, AgentEnvelope v2, and self-repair.

Agent Substrate: the core system

A runtime substrate that turns an agent's execution into a reversible, Git-like trace, so meta-agents can observe, fork, replay, and revert any run. Couples agent and environments in a copy-on-write fork ~5x faster than docker commit, with ~95% KV-cache reuse on replay. Framework built for meta-agents to supervise, optimize, and train other agents

BREAD: one vocabulary, two operators. A no-build, AI-native web stack: batch (substrate) · grain (design system) · mill (CMS) · proof (plan board) · crumb (guided tours).