C library for high-throughput sequencing data formats
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Pysam is a Python package for reading, manipulating, and writing genomics data such as SAM/BAM/CRAM and VCF/BCF files. It's a lightweight wrapper of the HTSlib API, the same one that powers samtools, bcftools, and tabix.
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cython + htslib == fast VCF and BCF processing
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